Research Areas

(1) Organic Synthetic Chemistry, with a focus on the design and development of efficient and innovative synthetic methodologies; (2) Medicinal Chemistry, particularly the identification and optimization of biologically active compounds for potential therapeutic applications; and (3) Natural Product Chemistry, including the isolation, structural elucidation, and derivitization to enhance biological activity and pharmacological potential.,

Profile

Fostino earned a PhD in Organic Chemistry from the University of Wollongong, Australia in 2025, within the Faculty of Science, Medicine and Health, under the supervision of Dr Sinead T. Keaveney and Prof Paul Keller. His research focuses on the development of efficient and innovative approaches for the preparation of biologically active compounds, with potential applications in drug discovery and pharmaceutical development.

Publications

• Journal Article
  Bokosi, F. R. B.; Richardson, C.; Keaveney, S. T. Light-Induced 1(2H)-Isoquinolone Synthesis via Regioselective Denitrogenative [4+2] Transannulation of 1,2,3-Benzotriazin-4(3H)-ones with Allenes. ChemistrySelect 2025, 10 (41), e05035. DOI: https://doi.org/10.1002/slct.202505035. (2025)
  https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.202505035

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• Book Chapters
  Bokosi, F. R. B.; Reza, T.; Keaveney, S. T. Chapter Two - Denitrogenative transformations of aryl-fused 1,2,3-triazoles. In Advances in Heterocyclic Chemistry, Scriven, E. F. V., Ramsden, C. A. Eds.; Vol. 147; Academic Press, 2025; pp 77-131. (2025)
  https://www.sciencedirect.com/science/chapter/bookseries/abs/pii/S0065272525000248

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• Journal Article
  Bokosi, F. R. B.; Shiels, O. J.; Richardson, C.; Trevitt, A. J.; Keaveney, S. T. Divergent Reactivity of 1,2,3-Benzotriazin-4(3H)-ones: Photocatalytic Synthesis of 3-Substituted Isoindolinones Achieved through a Nitrogen-Mediated Hydrogen Atom Shift. J. Org. Chem. 2024, 89 (3), 1836-1845. DOI: 10.1021/acs.joc.3c02545. (2024)
  https://pubs.acs.org/doi/abs/10.1021/acs.joc.3c02545

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• Journal Article
  Bokosi, F. R. B.; Shiels, O. J.; Trevitt, A. J.; Keaveney, S. T. Photoactivated Reactions without Traditional Photocatalysts: Electron-Donor Complexation of 1,2,3-Triazoles Initiates Denitrogenative Transformations. J. Org. Chem. 2024, 89 (18), 13243-13252. DOI: 10.1021/acs.joc.4c01371. (2024)
  https://pubs.acs.org/doi/10.1021/acs.joc.4c01371

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• Journal Article
  Shiels, O. J.; Menti-Platten, M.; Bokosi, F. R. B.; Burns, B. R.; Keaveney, S. T.; Keller, P. A.; Barker, P. J.; Trevitt, A. J. A Photoreactor-Interfaced Mass Spectrometer: An Online Platform to Monitor Photochemical Reactions. Anal. Chem. 2023, 95 (42), 15472-15476. DOI: 10.1021/acs.analchem.3c03294. (2023)
  https://pubs.acs.org/doi/10.1021/acs.analchem.3c03294

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• Journal Article
  Bokosi, F. R. B., & Ngoepe, M. P., Synthesis, in silico docking studies and antiplasmodial activity of hybrid molecules bearing 7-substituted-4-aminoquinoline moiety and cinnamic acid derivatives. Chemical Biology and Drug Design, (2022), https://doi.org/10.1111/cbdd.14050. (2022)
  https://onlinelibrary.wiley.com/doi/10.1111/cbdd.14050

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• Journal Article
  Bokosi F.R.B., Beteck R.M., Mbaba M., Mtshare T.E., Laming D., Hoppe H.C., Khanye S.D, Design, synthesis and biological evaluation of mono- and bisquinoline methanamine derivatives as potential antiplasmodial agents, Bioorganic and Medicinal Chemistry Letters, 38, (2021), https://doi.org/10.1016/j.bmcl.2021.127855. (2021)
  https://www.sciencedirect.com/science/article/pii/S0960894X21000810

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• Journal Article
  Bokosi F.R.B., Beteck R.M., Laming D., Hoppe H.C., Tshiwawa T., Khanye S.D., Synthesis of 2-(N-cyclicamino) quinoline combined with methyl (E)-3-(2/3/4- aminophenyl) acrylates as potential antiparasitic agents, Archiv der Pharmazie, 354, 7, (2021), e2000331. https://doi.org/10.1002/ardp.202000331. (2021)
  https://onlinelibrary.wiley.com/doi/epdf/10.1002/ardp.202000331

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• Journal Article
  Bokosi F.R.B., Beteck R.M., Jordaan A., Seldon R., Warner D., Tshiwawa T., Lobb K., Khanye S.D., Arylquinolinecarboxamides: Synthesis, in vitro and in silico studies against Mycobacterium tuberculosis, Journal of Heterocyclic Chemistry, (2021), https://doi.org/10.1002/JHET.4340. (2021)
  https://onlinelibrary.wiley.com/doi/full/10.1002/jhet.4340

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